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June 22 Responding To a Few CommentsWow! I am amazed at the amount and content of all these comments! Allow me to take a moment to respond to a few (especially plunge from the Irreducible Complexity post) before moving on. It appears that many are getting very technical in their assessment of the debate. That is entirely fine. I have tried to keep my posts easy to read for everyone, but in this one instance we need to combat science with REAL science. So, be fore warned, you asked for it! First and foremost, many people have underestimated the power of evolution, and many people assume I make the same underestimation. For anyone reading, evolution (natural selection) most certainly occurs. We can clearly see that in the divergence of reproductively isolated species in all major taxa. My major question has always been, and continues to be, to wonder if this type of evolutionary change can account for the divergence of all life on planet Earth? Furthermore, how did this original life come into existence in the first place? It was certainly not by an evolutionary mechanism because this is outside the realm of evolution. (See post on Abiogenesis) Now to respond to a few pointed comments.
Writer “Trav-ling”, jumped to the mutation question before I could post and stated that Floyd Romesberg indicated that E. coli can promote a mutation in protein LexA to initiate antibiotic resistance. This is partially true. We see many organisms (insects, the flu, bacteria) who seem to develop some form of resistance to toxins. However, what you failed to mention is that this resistance typically comes at a high price. When the “wild type” (biology term for naturally occurring organism) is reintroduced into the population they rapidly out-compete the mutants and kill them off. As for your specific example the reason LexA comes with this fitness cost is because it specifically inhibits transcription of lexA and recA (40bp and 20bp respectively). These genes are critical to inducing the cells pleiotropic response (typically called the “SOS” response). This is damaging because the SOS response is a cells last ditch effort to save itself after considerable DNA damage. (Need a reference: Little et al. PNAS 81) So you are only partially correct in your statement. Many assert that sickle cells are a beneficial mutation as well, because they inhibit malaria. Excuse me, but I would rather take the malaria any day before the sickle cell anemia. (If you are not sure why look up the symptoms of sickle cell anemia.)
Another writer “Geoff Coupe” stated “One might almost believe that you've never followed the discussions over at The Panda's Thumb”. Come on now Geoff. I have been doing this for six years. I am well aquatinted with Gould’s argument about the Panda’s thumb. Few quick comments. Does that prove that a single celled organism can evolve into anything but a single cell. No. Furthermore, this looks more like the action of Natural selection reducing any over complicated system more than creating an entirely new one. Natural selection tends to get rid of things that are excessive or unnecessary. (It does this much more than it creates new systems. Look up Runaway Selection.) The panda’s thumb seems to me to be the simplification of a preexisting structure, more than a novel feature.
Lastly to the very vocal “Plunge”. You stated that Behe retorted his argument. Not true. When I spoke with him a few years ago he seemed more convinced of it than ever before. Check out his latest publication and I think you will be quite convinced. Secondly you questioned why modern cells had to spring into existence all at once. Let me ask you, exactly which major system of the cell would you remove first? “Modern” cells are not very different than proposed primitive cells in their basic design. I urge you to re-read the post on abiogenesis and consider the simple fact that all of the cells major systems to fulfill the seven keys to life have to be in place for even the first life to arise. Then to my statement that we have numerous examples of systems which cannot be derived by numerous slight modifications you said: Prove it. Think about the fact that amino acids (proteins) have to be constructed through use of an enzyme, which amazingly enough, is also a protein! Furthermore, aminoacytly-tRNA synthase is required to attach the amino acid to the tRNA. Without these systems you cannot construct proteins. How can the whole ribosome system be reduced? Show me. Want another? How about DNA replication? Imagine a world without DNA polymerase and the various molecular machines (like the helicase & primase) that help preserve the integrity of DNA. Furthermore, DNA replication is required for reproduction. What good is a cell that cannot reproduce? Prove to me how replication and transcription evolved and you will make major strides in convincing me that we might have a naturalistic origin. (You won’t find one by the way. I have been looking for years.) Also, I am glad you mentioned the Kreb Cycle and Blood Clotting evolution. Give me your references, because all the work I have ever seen about these systems never proposes to demonstrate the mechanism of evolution. Once I have those I will be happy to address them publicly.
In conclusion, I want to thank all of you for your comments. I have been trying to keep up with all the statements and have had a lot of fun reading them. Keep up the good discussion. Don’t forget Scientific Integrity is what this site is all about. Comments (12)
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