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August 30 Responding to a few CommentsAs I suspected the Mutations blog caused a stir of very good comments from four well informed individuals. Ignoring comments degrading my intellectual integrity, education, or attempts at apologetics I will attempt to quickly address some of the relevant comments before moving on. It is possible that an adequate response will require a more in-depth scientific approach; so I apologize to those casual readers who are not well versed in scientific disciplines. “Plunge” made the comment that “There is no such thing as a purely, universally beneficial mutation”. And that higher fitness of parent bacteria is to be expected. We agree. Plunge realizes that the mutant strains come with certain defects. As was stated, even seemingly beneficial mutations come with a host of deleterious effects. Those deleterious effects tend to accumulate more rapidly than any beneficial effect. This is the central point of the example. Some studies have demonstrated temporary amelioration of costs, no doubt, but others clearly demonstrate that the fitness costs have huge negative ramifications. (See Sniegowski et. al, BioEssays, Nov, 2000) All of the commenters made remarks on the evolution of novel tissue types. I have to believe that none of you have done adequate research into the differentiation of primordial germ cells. Let’s take the incredible example of Shh working through Gli (a 5-zinc fingered TF). Notice that for any mutation to have a phenotypic expression it would have to A) hijack a current TF to activate the expression of the mutated gene (referred to as a protooncogene, which induce tumor formation.) or B) it would have to develop, simultaneously, a new signal transduction pathway to activate expression of this new mutation for further growth. But I stopped short in my argument before. This mutated cell would also need to find a way to initiate lateral inhibition, lest it too become tumorous. In direct response to “plunge” this does become a make or break necessity for evolving novel systems. In response to “David”, I understand and agree with your statement regarding homogeneity. Certainly there are mechanisms that allow for adaptive change in response to environmental stimuli. (Homologous recombination is an admittedly very good mechanism of natural selection and speciation.) To further address your question over the point of “ID”, it is testable and provable, that new species have and can arise through natural selection. Some of my own research has indicated this very premise. Evolution is great at tinkering with the currently available resources. Evolution, as stated before, is not adequate to explain the appearance of novel morphological features. Some believe that the common wrote answer is to claim the power of mutations. This argument does not stand up under a clear scrutiny of the nature of mutations. Have we ever, despite all human attempts, seen any mutation that gives a morphological selective advantage to any species? The answer is … No. I do not claim a religious agenda, yet this is another factor that causes me to seriously question the ability of evolution to explain the diversity of life.
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